Diamine Oxidase Supplement Side Effects

Diamine oxidase supplement side effects – Diamine oxidase enzyme or DAO is placed within the intestinal mucosa specially, accordingly acts at some stage in the digestion of meals. the main cause of the enzymatic dysfunction has a genetic origin. a few people have or produce few Diamine Oxidase, that is the purpose why till these days, migraine changed into believed to be hereditary, while in truth; the hereditary component is the deficiency of DAO. moreover, tablets or a few inflammatory bowel diseases constitute some other thing that permits histamine decrease.

Diamine oxidase supplement side effects – Histamine intolerance or sensitivity is because of a construct-up of histamine inside the body to a degree that exceeds the amount required for normal functioning.  The extra histamine consequences in signs and symptoms that resemble hypersensitivity.  below regular conditions, extra histamine is damaged down by way of particular enzymes, in particular diamine oxidase (DAO).   the goods of histamine breakdown are then excreted via the kidneys in urine.

Diamine oxidase supplement side effects
Diamine oxidase supplement side effects


However, when the amount of DAO is insufficient to deal with the excess, histamine levels rise and typical histamine sensitivity symptoms develop.

DAO acts on histamine both outside and inside the body. in the body, DAO is located mainly within the kidneys, thymus, and the placenta in pregnant ladies. while histamine stages within the body emerge as immoderate, DAO, and any other enzyme called histamine N-methyl transferase (HNMT) smash down the excess.  excess histamine can rise inside the frame (referred to as endogenous histamine) as it’s far released from mast cells in some of conditions together with hypersensitive reaction, mast cellular activation problems, chronic inflammation, contamination, and trauma, among others.

Diamine oxidase supplement side effects – the symptoms

When there is an accumulation of histamine many body systems can be altered, but symptoms don’t necessarily have to appear in all patients. The most typical are:


  • Central Nervous System: Migraine, headaches and/or dizziness.
  • Digestive System: Irritable Bowel Syndrome (diarrhea, constipation), Crohn disease, stomach pain, nausea and/or vomiting.
  • Cardiovascular System: hypotension, hypertension and/or arrhythmia.
  • Epythelium: hives, oedema, atopic skin, eczema and/or rach.
  • Respiratory System: nose congestion, rhinitis, asthma and/or sneezing.
  • Muscular System: muscle pain, fibromyalgia and/or fatigue.
  • Bone System: bone pain.


Due to the wide variety of symptoms derived from DAO deficiency, which represent chronic pathologies with a high prevalence in population, immediate research and advances on its origin and possible treatments are required.

Diamine oxidase supplement side effects – Study case

“We diagnosed 137 patients who have a migraine, of whom 119 showed deficits of the activity of the enzyme, around 87% of the total patients that we have studied,” said Joan Izquierdo, MD, from the Faculty of Health Sciences at the International University of Catalonia and the neurology service at Catalonia General Hospital in Barcelona, Spain.

He said normal enzyme activity is a score of at least 80 histamine-degrading units [HDU]/mL.

In a survey administered in 2006 and again in 2012, symptom scores correlated with enzyme activity. Symptom scores rose progressively as enzyme activity dropped below 80 HDU/mL, with scores 50% to 120% higher in the 30-40 HDU/mL range compared with enzyme activity >80 HDU/mL.

Speaking here at the XXI World Congress of Neurology (WCN), Dr. Izquierdo presented the results of his single-center, double-blind, placebo-controlled trial of DAO oral supplementation, called MIGRADAO 002, as a preventive treatment in patients with DAO activity less than 80 HDU/mL and episodic migraine with or without aura, diagnosed according to the criteria of the International Headache Society.

Participants were men or women age 18 to 60 years old with an attack within the previous 6 months. Most of the patients were women, with only 8 men in each group. The placebo and medication groups were well matched for median age (approximately 40 years) and age range (18 to 65 years).

Major exclusions were alcoholism, psychiatric disorders, or a diagnosis of any disorder for which a treatment could be used as migraine prevention in the previous 1 month. People with religious convictions prohibiting the consumption of pork products were also excluded because of the porcine origin of the DAO supplement.


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